Question 1

What exactly is GLP-1 medication?

Accepted Answer

GLP-1 medication is a class of drugs that mimics the natural gut hormone GLP-1. This hormone plays a central role in regulating appetite, satiety, and blood sugar levels. By supplementing this hormone externally, patients experience less hunger and feel full sooner, leading to consistent and safe weight loss.

Question 2

Which medications does Go Leaner prescribe?

Accepted Answer

We work with five scientifically backed medications: Mounjaro (tirzepatide), Wegovy (semaglutide 2.4 mg), Ozempic (semaglutide), Saxenda (liraglutide), and Mysimba (naltrexone/bupropion). The first four are injections (pen injectors), Mysimba is a tablet. Which medication fits best is determined by your physician based on the intake.

Question 3

What's the difference between Ozempic and Wegovy?

Accepted Answer

Both contain the same active ingredient (semaglutide). Wegovy is specifically approved for weight management and available at a higher dose (up to 2.4 mg per week) than Ozempic (up to 2 mg). In practice, Wegovy therefore leads to slightly more weight loss on average.

Question 4

Why is Mounjaro often more effective?

Accepted Answer

Mounjaro contains tirzepatide, which acts on two hormone receptors simultaneously: GLP-1 and GIP. This dual action provides a stronger satiety effect and improved metabolism. In the SURMOUNT trials, the average participant achieved up to 22.5% weight loss — the highest percentage ever measured in a clinical obesity study.

Question 5

Is Saxenda still relevant alongside newer medications?

Accepted Answer

Absolutely. Saxenda (liraglutide) has a longer track record than semaglutide and tirzepatide. For some patients it works better due to a more favorable side effect profile or specific medical considerations. Daily administration also offers more dosing flexibility.

Question 6

What if I prefer not to use injections?

Accepted Answer

Then Mysimba is an option. This is a tablet treatment with naltrexone and bupropion that doesn't work via the GLP-1 system, but influences the reward system in the brain. It's particularly suited for people where emotional eating or cravings play a major role.

Question 7

What are the most common side effects?

Accepted Answer

Most GLP-1 medications (Mounjaro, Wegovy, Ozempic, Saxenda) cause mild gastrointestinal symptoms such as nausea in some patients, which usually subside within a few weeks. For Mysimba, nausea and headache are the most common side effects. By gradually increasing the dose, we minimize these effects.

Question 8

Is weight loss medication covered by health insurance?

Accepted Answer

GLP-1 medication for weight loss is currently not covered by basic Dutch health insurance. Some supplementary policies offer partial coverage for obesity treatment. We advise you to check with your insurer in advance.

Question 9

Can I switch medication during treatment?

Accepted Answer

Yes. If a medication doesn't have the desired effect or you experience side effects, your physician can switch you to a different medication. This is not an exception — it's part of careful treatment.

Question 10

How quickly will I see results?

Accepted Answer

Most patients notice reduced appetite and initial weight loss within 2 to 4 weeks. Maximum effect occurs after full titration (gradually building up to the optimal dose), which typically takes 3 to 4 months.

Medication	Mounjaro	Wegovy	Ozempic	Saxenda	Mysimba
Active ingredient	Tirzepatide	Semaglutide	Semaglutide	Liraglutide	Naltrexone / Bupropion
Administration	1× per week	1× per week	1× per week	1× per day	2× per day
Target group	Overweight: BMI ≥ 30, or BMI ≥ 27 with a weight-related condition	Overweight: BMI ≥ 30, or BMI ≥ 27 with a weight-related condition	Overweight: BMI ≥ 30, or BMI ≥ 27 with a weight-related condition	Overweight: BMI ≥ 30, or BMI ≥ 27 with a weight-related condition	Overweight: BMI ≥ 30, or BMI ≥ 27 with a weight-related condition
How it works	This medication mimics two natural gut hormones: GLP-1 and GIP. Together they regulate appetite, enhance satiety, and improve metabolism. The dual action makes this the most potent available medication in this class.	This medication mimics the natural gut hormone GLP-1. It suppresses appetite, enhances satiety, and improves sugar metabolism. Available at the highest possible semaglutide dose (2.4 mg).	This medication mimics the natural gut hormone GLP-1. It suppresses appetite, enhances satiety, and improves sugar metabolism. Originally developed for type 2 diabetes, widely used for overweight.	This medication mimics the natural gut hormone GLP-1. It suppresses appetite, enhances satiety, and improves sugar metabolism. Daily administration offers precise dosage control.	The active substances in this medication influence the reward system in the brain. This reduces appetite, cravings, and urges for sweets and snacks — without injection.
Potential weight loss	Average 15–22% weight loss	Average 10–15% weight loss	Average 10–15% weight loss	Average 8–10% weight loss	Average 5–8% weight loss
Most common side effects	Nausea, gastrointestinal symptoms and fatigue. Symptoms typically decrease over time.	Nausea, gastrointestinal symptoms and fatigue. Symptoms typically decrease over time.	Nausea, gastrointestinal symptoms and fatigue. Symptoms typically decrease over time.	Nausea, gastrointestinal symptoms and fatigue. Symptoms typically decrease over time.	Nausea, gastrointestinal symptoms and fatigue. Symptoms typically decrease over time.
	Learn more	Learn more	Learn more	Learn more	Learn more

Medication Overview

Mounjaro

Wegovy

Ozempic

Saxenda

Mysimba

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Frequently asked questions about weight loss medication

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